Pyridoxine vitamin b 6 , deficiency is sometimes observed in adults with high doses of myambutol-inh isoniazid and is considered probably due to its competition with pyridoxal phosphate for the enzyme apotryptophanase.

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untoward effects of isoniazid therapy, including severe hepatitis, in otherwise healthy infants, children, and adolescents are rare.

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when active tuberculosis is identified, combination therapy with isoniazid, rifampin, pyrazinamide, and ethambutol should be promptly initiated for a two-month intensive phase, and in most cases, followed by isoniazid and a rifamycin product for a four-to seven-month continuation phase.


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